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Bioinformatics with Python Cookbook

You're reading from   Bioinformatics with Python Cookbook Learn how to use modern Python bioinformatics libraries and applications to do cutting-edge research in computational biology

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Product type Paperback
Published in Jun 2015
Publisher
ISBN-13 9781782175117
Length 306 pages
Edition 1st Edition
Languages
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Toc

Table of Contents (11) Chapters Close

Preface 1. Python and the Surrounding Software Ecology 2. Next-generation Sequencing FREE CHAPTER 3. Working with Genomes 4. Population Genetics 5. Population Genetics Simulation 6. Phylogenetics 7. Using the Protein Data Bank 8. Other Topics in Bioinformatics 9. Python for Big Genomics Datasets Index

Introduction

In the previous chapter, we used Python to analyze population genetics datasets based on real data. In this chapter, we will see how to use Python to simulate population genetics data. From teaching to developing new statistical methods or to analyze the performance of existing methods, simulated datasets have plenty of applications.

There are two kinds of simulation. One is coalescent simulation that goes backwards in time. Second is forward time. As the name implies, it simulates going forward. The coalescent simulation is computationally less expensive because only the most recent generation of individuals need to be completely rendered; previous generations only need parents of the previous generation to be maintained. On the other hand, this severely limits what can be simulated because we need to complete populations to make decisions on e.g. which individuals mate. Forward time simulations are computationally more demanding and normally more complex to code, but they...

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